Depression, cant cope anymore?

i have spouts of sever depression, and i have just started a new "low" and family and friends are not there for me. tried talking to a friends about it yesterday, thought i could count on her and she told me to get over it and i stormed of and now shes ignoring me. im fed up. i am on high dose of meds and seeing concealer and phyciactris. and it was hard before with the Support from friends and family, but now without them, i don't know how to cope, the emotional pain is so Intense. please can somebody give me a Solution or advice. thank you